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Strategy for Stabilizing Enzymes Part Two: Increasing Enzyme Stability by Selective Chemical Modification |
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| Authors: | V. V. Mozhaev N. S. Melik-nubarov Virginius &#x ik&#x nis Karel Martinek |
| Affiliation: | a Chemistry Department, Moscow State University, Moscow, USSRb All-Union Research Institute of Applied Enzymology, Vilnius, Lithuanian, SSRc Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia |
| Abstract: | The molecular mechanisms of change in the thermal stability of proteins modified with low molecular weight reagents are discussed. The choice of stabilization mechanisms to be used as a general strategy for increasing enzyme stability by chemical modification is addressed. Hydrophilization of nonpolar surface areas is the most simple and reliable approach to artificial stabilization of enzymes for use in applied biochemistry and biotechnology. |
| Keywords: | Enzymes stability of covalent modification of hydrophilization of |
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