首页 | 本学科首页   官方微博 | 高级检索  
     


Isolation of a cDNA for the rat heavy neurofilament polypeptide (NF-H)
Authors:P A Robinson  D Wion  B H Anderton
Affiliation:Department of Immunology, St. George''s Hospital Medical School, Cranmer Terrace, London SW17 ORE, England
Abstract:We have isolated from a rat brain lambda gt11 expression library two overlapping cDNA clones of sizes 2.5 and 3.0 kb corresponding to the heavy neurofilament polypeptide (NF-H). The 2.5 kb insert apparently represents virtually the whole of the C-terminal tail, the 3.0 kb insert also encodes the conserved epitope for the monoclonal antibody, anti-IFA. The identity of the cDNAs was established by comparison of the predicted amino acid sequence with the known partial amino acid sequence of porcine NF-H. A repeat peptide sequence that may be a multiphosphorylation site was identified in the C-terminal non-helical tail.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号