计算识别microRNA及其靶基因

小RNA的发现为基因调控系统研究提供了新的方向。在多数物种中已经发现了大量的小RNA。这一领域已经成为了近来研究的热点，在研究起始阶段，计算学方法已经成为实验研究中不可或缺的工具，许多发现是由生物学实验与计算学方法共同合作来完成的。在这篇综述中，我们总结了前人关于小RNA及其靶基因识别的理论知识。最后，讨论了关于预测小RNA及其靶基因的计算学方法和相关软件。

Computational Identification of microRNAs and Their Targets

The discovery of microRNAs (miRNAs) has introduced a new paradigm into gene regulatory systems. Since inception, computational methods have been an invaluable tool complementing experimental approaches, and many discoveries have been obtained through combination of experimental and computational approaches. In this review, we summarize the knowledge that has been accumulated about the principles of miRNAs and target recognition. The currently available computational methodologies and software for prediction of miRNA and their target genes also have been discussed.