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Analysis of brain metabolism by proton magnetic resonance spectroscopy (1H-MRS) in attention-deficit/hyperactivity disorder suggests a generalized differential ontogenic pattern from controls |
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| Authors: | Mauricio Arcos-Burgos Ana C. Londo?o David A. Pineda Francisco Lopera Juan David Palacio Andres Arbelaez Maria T. Acosta Jorge I. Vélez Francisco Xavier Castellanos Maximilian Muenke |
| Affiliation: | 1. Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 35, Room 1B-209, Bethesda, MD, 20892-3717, USA 2. John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia 3. Neurosciences Group, University of Antioquia, Medell??n, Colombia 4. Neurological Institute of Antioquia, Medell??n, Colombia 5. New York University Child Study Center, New York, NY, USA 6. Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA |
| Abstract: | Attention-deficit/hyperactivity disorder (ADHD) is the most common behavioral disorder of childhood. Preliminary studies with proton magnetic resonance spectroscopy (1H-MRS) of the brain have reported differences in brain metabolite concentration-to-Cr ratios between individuals with ADHD and unaffected controls in several frontal brain regions including anterior cingulate cortex. Using multivoxel 1H-MRS, we compared 14 individuals affected with ADHD to 20 individuals without ADHD from the same genetic isolate. After controlling by sex, age, and multiple testing, we found significant differences at the right posterior cingulate of the Glx/Cr ratio density distribution function between ADHD cases and controls (P? |
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