中药大蓟化学成分的研究

从大蓟的50％乙醇提取物中分离得到2个木脂素：（-）2-（3’-甲氧基4’-羟基-苯基）-3，4-二羟基4-（3＂-4＂-羟基-苄基）-3-四氢呋哺甲醇（1）和络石苷（2），以及另外6个化合物：蒙花苷（3）、柳穿鱼叶苷（4）、粗毛豚草素（5）、芹菜素（6）、咖啡酸（7）和对-香豆酸（8）。本文首次在蓟属植物中发现木脂素类成分，化合物7也为首次从本植物中分离得到，通过体外玻片法对化合物1—8进行凝血活性测定，发现化合物3、4具有一定的促凝血作用。

Phytochemical Investigation of Cirsium japonicum DC.

Two lignans, (-) 3, 4-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-(4-hydroxy-3-methoxybenzyl)-3-tetra-hydrofuranmethanol (1) and tracheloside (2) , together with other six compounds, linarin (3) , pectolinarin (4), hispidulin (5) , apigenin (6) , caffeic acid (7) , and p-eoumaric acid (8) were isolated from the 50% ethanol extract of the whole herb of Cirsium japonicum DC.. This is first reported that lignan was discovered in the genus Cirsium and compound 7 was first isolated from this species. Compounds 3 and 4 have been shown to have the hemostatic activity in vitro.