G Protein-coupled Receptor (GPCR) Signaling via Heterotrimeric G Proteins from Endosomes |
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| Authors: | Nikoleta G Tsvetanova Roshanak Irannejad Mark von Zastrow |
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| Institution: | From the Departments of ‡Psychiatry and ;§Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158 |
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| Abstract: | Some G protein-coupled receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear to elicit a “second wave” of G protein activation after ligand-induced internalization. We briefly summarize evidence supporting this view and then discuss what is presently known about the functional significance of GPCR-G protein activation in endosomes. Endosomal activation can shape the cellular response temporally by prolonging its overall duration, and may shape the response spatially by moving the location of intracellular second messenger production relative to effectors. |
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