Inhibition of lipid peroxidation |
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| Authors: | Enjie Sun Huibi Xu Dijiang Wen Ping Zuo Jingyan Zhou Jünjian Wang |
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| Institution: | (1) Chemistry Department, Huazhong University of Science and Technology, 430074 Wuhan, People’s Republic of China;(2) Biology Department, Huazhong University of Science and Technology, 430074 Wuhan, People’s Republic of China;(3) Institute of Material Science and Technology, Wuhan University of Science and Technology, People’s Republic of China |
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| Abstract: | Lipid peroxy radicals (ROO-) were detected by electron spin resonance (ESR) at low temperature after formation by addition
of H2O2 into a suspension of mice lymphocites. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO-formation was inhibited in a fashion that was dependent on Se-Met concentration. Formation of ROO- in the spleen of
mice was induced by60Co irradiation. Animals that were supplemented with Na2SeO3 prior to irradiation exhibited a lower ROO-concentration than that of nontreated animals. Based on our experiments, we have
concluded that Se has an oxygen-free radical scavenging effect. This should be a protective effect against lipid peroxy radical
cellular attack. |
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| Keywords: | Selenium lipid peroxy radical ESR H2O2 60Co radiation |
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