Antiviral activity of fattiviracin FV-8 against human immunodeficiency virus type 1 (HIV-1) |
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Authors: | Habib E S Yokomizo K Nagao K Harada S Uyeda M |
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Institution: | Faculty of Pharmaceutical Sciences, Kumamoto University, Japan. |
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Abstract: | A novel antiviral agent, fattiviracin FV-8, purified from the culture broth of Streptomyces microflavus strain No. 2445, showed potent antiviral activities against human immunodeficiency virus type 1 (HIV-1), herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), and influenza A and B viruses. The action mechanism of fattiviracin FV-8 against HIV-1 was examined. As a result, the agent was thought to act on HIV-1 particles directly without lysis of the particles, and it affords the inhibition of viral entry into the host cells. |
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