|
|||||
|
|
Primate-specific spliced <Emphasis Type="Italic">PMCHL</Emphasis> RNAs are non-protein coding in human and macaque tissues |
|
| Authors: | Sandra Schmieder Fleur Darré-Toulemonde Marie-Jeanne Arguel Audrey Delerue-Audegond Richard Christen Jean-Louis Nahon |
| Institution: | 1.Université de Nice-Sophia Antipolis, CNRS,Institut de Pharmacologie Moléculaire et Cellulaire,Valbonne,France;2.Biothèque Primates/Primatech,Centre National de la Recherche Scientifique, Life Science Department,Bordeaux-Valbonne,France;3.Université de Nice-Sophia Antipolis, CNRS,Virtual Biology Lab,Parc Valrose,Nice,France;4.Institut de Biologia Evolutiva (UPF-CSIC), CEXS-UPF-PRBB,Barcelona,Spain |
| Abstract: | BackgroundBrain-expressed genes that were created in primate lineage represent obvious candidates to investigate molecular mechanisms that contributed to neural reorganization and emergence of new behavioural functions in Homo sapiens. PMCHL1 arose from retroposition of a pro-melanin-concentrating hormone (PMCH) antisense mRNA on the ancestral human chromosome 5p14 when platyrrhines and catarrhines diverged. Mutations before divergence of hylobatidae led to creation of new exons and finally PMCHL1 duplicated in an ancestor of hominids to generate PMCHL2 at the human chromosome 5q13. A complex pattern of spliced and unspliced PMCHL RNAs were found in human brain and testis. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |