Antiproliferative function of glia maturation factor beta. |
| |
| Authors: | R Lim W X Zhong A Zaheer |
| |
| Affiliation: | Department of Neurology, University of Iowa College of Medicine, Iowa City. |
| |
| Abstract: | Recombinant human glia maturation factor beta (GMF-beta) reversibly inhibits the proliferation of neoplastic cells in culture by arresting the cells in the G0/G1 phase. This phenomenon is not target-cell specific, as neural and nonneural cells are equally inhibited. When tested simultaneously, GMF-beta suppresses the mitogenic effect of acidic fibroblasts growth factor (aFGF), but the two are synergistic in promoting the morphologic differentiation of cultured astrocytes. GMF-beta also counteracts the growth-stimulating effect of pituitary extract and cholera toxin on Schwann cells. The results underscore the regulatory role of GMF-beta and its intricate interaction with the mitogenic growth factors. |
| |
| Keywords: | |
|
|
