The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells |
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Authors: | Ansgar Brüning Josef Makovitzky Andrea Gingelmaier Klaus Friese Ioannis Mylonas |
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Institution: | (1) 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians University Munich, Maistrasse 11, 80337 Munich, Germany;(2) Department of Neuropathology, University of Heidelberg, Heidelberg, Germany |
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Abstract: | Normal placenta development relies on the ability of trophoblast cells to invade into the uterus and to build up an extensively
vascularized feto-maternal tissue, necessary for the nutrition of the embryo. The ability of cell migration, invasion, and
the ability to induce neovascularization are likewise hallmarks of cancer cells. The metastasis-associated genes MTA1 and
MTA3 are known to be involved in cancer cell migration by regulation of cell adhesion proteins and to induce the expression
of neoangiogenic cytokines, as recently shown by us for ovarian cancer cells. Therefore, we analyzed the expression of MTA1
and MTA3 in normal human placenta tissues and the chorionic cancer cell lines BeWo, JEG, and JAR. Immunohistochemical analysis
revealed a rather strong expression of MTA1 and MTA3 in the nuclei of human trophoblast cells. A high expression level of
MTA1 and MTA3 was further observed in the nuclei of human chorionic carcinoma cells, as shown by immunofluorescence analysis,
and confirmed by Western blot and RT-PCR analysis. We conclude that the high expression level of MTA proteins in human chorionic
cells might facilitate trophoblast cell migration and neoangiogenesis, and might further predispose human chorionic cancer
cells with properties that are characteristic for this highly aggressive and metastatic carcinoma type. |
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Keywords: | MTA1 MTA3 Placenta Chorionic carcinoma |
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