| 喘可治注射液对小鼠体外CD4+CD25+T细胞的影响 |
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| 引用本文： | 王幼萍,曾耀英,肇静娴. 喘可治注射液对小鼠体外CD4+CD25+T细胞的影响[J]. 生命科学研究, 2006, 10(4): 338-341 |
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| 作者姓名： | 王幼萍 曾耀英 肇静娴 |
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| 作者单位： | 北京师范大学,珠海分校,中国广东,珠海,519085;暨南大学,组织移植与免疫实验中心,中国广东,广州,510632 |
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| 基金项目： | 国家自然科学基金资助项目(30500466)，广东省自然科学基金资助项目(05300419) |
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| 摘 要： | 利用荧光抗体标记和流式细胞术检测喘可治对刀豆蛋白A(ConA)诱导的T细胞CD69和CD25表达的影响,研究喘可治是否具有促进CD4 CD25 调节性T细胞升高的作用.结果发现喘可治对ConA诱导的T细胞活化标志分子CD69的表达具有抑制作用,但对CD25的表达具有促进作用.说明喘可治对T细胞活化具有抑制作用,CD25表达的上调并不是由活化引起的,而很可能是CD4 CD25 Tr水平升高的标志.
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| 关 键 词： | 喘可治 CD4+CD25+调节性T细胞 CD69 活化 |
| 文章编号： | 1007-7847(2006)04-0338-04 |
| 收稿时间： | 2006-09-30 |
| 修稿时间： | 2006-10-18 |
Effects of CKZ on Mouse CD4+ CD25+ T Cells in vitro |
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| WANG You-ping,ZENG Yao-ying,ZHAO Jing-xian. Effects of CKZ on Mouse CD4+ CD25+ T Cells in vitro[J]. Life Science Research, 2006, 10(4): 338-341 |
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| Authors: | WANG You-ping ZENG Yao-ying ZHAO Jing-xian |
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| Abstract: | To investigate whether Chinese medicine Chuankezhi(CKZ) functions in upregulation of CD4 CD25 regulatory T cells(Tr),fluorescence conjugated antibody labeling and flow cytometry were used to evaluate the effects of CKZ on expression of CD69 and CD25 on T cells induced by Concanavalin A(ConA).It was demonstrated that CKZ inhibited the expression of CD69,the early activation marker,and increased the expression of CD25 on T cells in response to ConA.These results suggested that CKZ had an inhibitory effect on T cell activation,and the increase in CD25 expression was not due to activation of T cells but a marker of upregulation of CD4 CD25 Tr. |
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| Keywords: | CKZ CD4 CD25 regulatory T cells CD69 activation |
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