Association of Malassezia to Atopic Dermatitis |
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Authors: | Adriana Valencia-Herrera Mirna Toledo-Bahena Erika Ramírez-Cortés Mario Duarte-Abdala Sonia Toussaint-Caire Carlos Mena-Cedillos Jade Castellanos Alexandro Bonifaz |
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Affiliation: | 1.Department of Dermatology,Hospital Infantil de México Federico Gómez,Ciudad de México,Mexico;2.Star Médica Hospital Infantil Privado,Mexico City,Mexico;3.Department of Dermatology, Allergy and Immunology,Hospital del Ni?o y del Adolescente Morelense,Mexico City,Mexico;4.Dermatology Division,Hospital General Dr. Manuel Gea González,Mexico City,Mexico;5.Dermatology & Mycology Service,Hospital General de México. Dr. Eduardo Liceaga,Mexico City,Mexico |
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Abstract: | Purpose of ReviewAtopic dermatitis (AD) is a common chronic, inherited, relapsing, inflammatory skin condition. A multifactorial etiology has been postulated, including genetic and immunological factors, impaired skin barrier function and environmental triggers, all of them are relevant in the pathogenesis. Malassezia spp. is the most common fungi of the skin microbiome. Most of the studies comparing the skin colonization with Malassezia spp. in healthy people and AD patients did not show difference between both groups. This review aims to show the studies carried out in this regard and the reported evidence about the role of Malassezia spp. in the pathogenesis of AD.Recent FindingsThe rate of IgE-mediated sensitization Malassezia spp. is very high in AD patients, mainly in adult patients and in patients with involvement in the head and neck. Different mechanisms have been postulated to explain the interaction of Malassezia spp. with human skin cells and immune cells and how its interaction contributes to the inflammation process in AD. Systemic and topical azole antifungals have been used with doubtful results showing beneficial effects in some AD patients.SummaryThere is no clear explanation for the high frequency of Malassezia spp. sensitization in AD patients in relation with healthy individuals. Further research is necessary to determine the specific role of Malassezia in AD and the indication for the use of antifungals in this disease. |
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