Information requirements and regulatory approaches for heritable genetic risk assessment and risk communication |
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Authors: | Kerry L. Dearfield |
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Affiliation: | U.S. Environmental Protection Agency, Office of Pesticide Programs (7509C), 401 M Street, S.W., Washington, DC 20460, USA |
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Abstract: | With the evolution of genetic toxicology as a scientific discipline and the formation of the Environmental Mutagen Society (EMS), much thought was given to the study of chemicals in the human environment for their mutagenic effects. The Society's goal was to promote scientific investigation and dissemination of information related to genetic toxicology. Subsequently, the concern for chemically induced genetic damage in human germ cells and its potential impact on genetic diseases was detailed in the Committee 17 Report (1975). With new information on the involvement of genetic alterations in disease and on the ramifications of possible effects of exposures to environmental mutagens, it is becoming increasingly necessary to again focus our attention on the assessment of heritable genetic effects. Clearly, strategies for communication of genetic hazard/risk assessments to exposed individuals and to those charged with regulating environmental agents need to be developed. |
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Keywords: | Heritable genetic risk Risk communication |
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