Catalytic action of selenium in the reduction of methemoglobin by glutathione |
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| Authors: | Tohru Masukawa Heitaroh Iwata |
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| Institution: | Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 133-1, Yamada-kami, Suita-shi, Osaka, Japan |
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| Abstract: | Selenite, selenate and selenocystine catalyzed the reduction of methemoglobin (metHb) by glutathione (GSH), while selenomethionine did not. Maximal reduction of metHb was observed with 10?5 M selenite and 2 mM GSH, at pH 7.4. Selenite also catalyzed the reduction of metHb with cysteine or 2-mercaptoethylamine in place of GSH. Heavy metals and arsenite completely prevented the effect of selenite. These findings suggest that certain seleno-compounds catalyze the reduction of metHb by thiol compounds. |
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