(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents |
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| Authors: | Dukat Małgorzata Taroua Mohamed Dahdouh Abdelaziz Siripurapu Umamaheswar Damaj M Imad Martin Billy R Glennon Richard A |
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| Institution: | Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA. |
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| Abstract: | Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown. |
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