Three-dimensional Model Structure for the Extracellular Domains of Fibroblast Growth Factor Receptor - 1 (FGFR-1)

We have developed a model for the two immunoglobulin-like extracellular domains DII and DIII of the FGF receptor 1 (FGFR-1), giving a special attention to the determination of the appropriate Ig set. The DII domain was aligned with the C-terminal domain of myosin light chain kinase (telokin) of the I set, and the DIII domain with the variable domain of the Bence-Jones immunoglobulin of the V set. Two assemblies, corresponding to different propositions for the domains relative orientation, have been refined and compared.Electronic Supplementary Material available.