LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations |
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Authors: | Yih Ru Wu Louis C Tan Xiaoli Fu Chiung Mei Chen Wing Lok Au Ling Chen Yi Chun Chen Kumar M Prakash Yifan Zheng Guey-Jen Lee-Chen Yi Zhao Jin-Sheng Zeng Eng King Tan Zhong Pei |
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Affiliation: | Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Linkou, Taiwan. yihruwu@adm.cgmh.org.tw |
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Abstract: | It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population. |
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