Developmental and pathological lymphangiogenesis: from models to human disease |
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Authors: | Hélène Maby-El Hajjami Tatiana V Petrova |
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Institution: | (1) Division of Experimental Oncology, Centre Pluridisciplinaire d’Oncologie, CHUV and University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland;(2) Molecular and Cancer Biology Research Program, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, 00014 Helsinki, Finland |
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Abstract: | The lymphatic vascular system, the body’s second vascular system present in vertebrates, has emerged in recent years as a
crucial player in normal and pathological processes. It participates in the maintenance of normal tissue fluid balance, the
immune functions of cellular and antigen trafficking and absorption of fatty acids and lipid-soluble vitamins in the gut.
Recent scientific discoveries have highlighted the role of lymphatic system in a number of pathologic conditions, including
lymphedema, inflammatory diseases, and tumor metastasis. Development of genetically modified animal models, identification
of lymphatic endothelial specific markers and regulators coupled with technological advances such as high-resolution imaging
and genome-wide approaches have been instrumental in understanding the major steps controling growth and remodeling of lymphatic
vessels. This review highlights the recent insights and developments in the field of lymphatic vascular biology. |
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Keywords: | Lymphangiogenesis Lymphedema Tumor metastasis Inflammation |
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