Diphenyl diselenide and diphenyl ditelluride: neurotoxic effect in brain of young rats, in vitro |
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| Authors: | Ana Cristina Guerra Souza Eluza Curte Stangherlin Ana Paula Ardais Cristina Wayne Nogueira |
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| Institution: | 1. Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil
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| Abstract: | This study examined whether maturity of rat brain may be relevant for the sensitivity to diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 on 3H]glutamate uptake and release, in vitro. Brain synaptosomes were isolated from young (14- and 30-day-old) and adult rats and incubated at different concentrations of (PhSe)2 or (PhTe)2. The results demonstrated that the highest concentration (100 μM) of (PhSe)2 and (PhTe)2 inhibited the 3H]glutamate uptake by synaptosomes of brain at all ages. In the adult brain, (PhSe)2 did not inhibit the 3H]glutamate uptake at the lowest concentration (10 μM). The highest concentration of (PhTe)2 inhibited the 3H]glutamate uptake more in the 14-day-old than in the 30-day-old rats or adult rats. In the 30-day-old animals, the highest concentration of (PhSe)2, and the lowest concentration of (PhTe)2, increased the basal 3H]glutamate release. At the highest concentration, (PhTe)2 increased the basal and K+-stimulated glutamate release on all ages evaluated. The results suggest that (PhSe)2 and (PhTe)2 caused alterations on the homeostasis of the glutamatergic system at the pre-synaptic level. These alterations were age-, concentration-, and compound-dependent. The maturity of rat brain is relevant for the glutamatergic system sensitivity to (PhSe)2 and (PhTe)2 . |
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