CD4+ cell memory: the enigma of Th1 cells |
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Authors: | Bradley Linda M |
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Affiliation: | Division of Immunology, The Sidney Kimmel Cancer Center, 10 835 Altman Row, San Diego, CA 92121, USA. lbradley@skcc.org |
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Abstract: | Despite a wealth of information pertaining to functional and phenotypic attributes of memory CD4(+) cells, the mechanisms that underlie the generation and persistence of memory in this subset are largely unknown. Recent work suggests that the development of memory might be differently regulated in T-helper-1 and T-helper-2 cells, owing to differences in their susceptibility to cell death. These studies support a new paradigm, in which memory T cells are heterogeneous in terms of their stage of maturation and function as well as mechanisms of homeostatic control. |
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