| 病毒性肝炎树鼩动物模型研究与建模策略 |
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| 引用本文： | 庞义全,冯悦,孙晓梅,刘丽,代解杰,夏雪山. 病毒性肝炎树鼩动物模型研究与建模策略[J]. 中国实验动物学报, 2014, 0(2): 95-102 |
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| 作者姓名： | 庞义全 冯悦 孙晓梅 刘丽 代解杰 夏雪山 |
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| 作者单位： | [1]昆明理工大学生命科学与技术学院,昆明650500 [2]中国医学科学院医学生物学研究所,昆明650118 |
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| 基金项目： | 国家自然科学基金（81260248,81360247）;国家科技支撑计划项目（2011BA115801-21,2012BAB9801,2014BAI01B01）. |
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| 摘 要： | 病毒性肝炎是由肝炎病毒引起的肝脏疾病。在我国,病毒性肝炎高度流行,其中又以乙型肝炎病毒(Hepatitis B virus,HBV)和丙型肝炎病毒(Hepatitis C virus,HCV)危害较大。动物模型是研究疾病感染与发病机制,进行药物与疫苗研究的必要工具。目前病毒性肝炎实验动物模型的研究已取得长足的发展,主要集中于病毒在动物体内的感染特性及发病规律方面。本文仅就病毒性肝炎动物模型,尤其乙型、丙型肝炎树鼩动物模型的研究及建模策略进行综述。
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| 关 键 词： | 病毒性肝炎 乙型肝炎 丙型肝炎 树鼩 动物模型 |
Research progress of tree shrew models of viral hepatitis and modeling strategy |
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| PANG Yi-quan,FENG Yue,SUN Xiao-mei,LIU Li,DAI Jie-jie,XIA Xue-shan. Research progress of tree shrew models of viral hepatitis and modeling strategy[J]. Acta Laboratorium Animalis Scientia Sinica, 2014, 0(2): 95-102 |
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| Authors: | PANG Yi-quan FENG Yue SUN Xiao-mei LIU Li DAI Jie-jie XIA Xue-shan |
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| Affiliation: | 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming Yunnan 650500, China; 2. Institute of Medical Biology, Chinese Academy of Medical Science ＆ Peking Union Medical College, Kunming 650118) |
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| Abstract: | Viral hepatitis is a major liver disease caused by virus infection. Viral hepatitis is popular in China, mainly caused by hepatitis B and hepatitis C viruses. Experimental animal model is a necessary platform for the research on mechanism of viral infection and pathogenicity, for treatment and vaccine development. Up to date, a great progress in the development of viral hepatitis animal models has been achieved in spite of the most of findings are limited to hepatitis B and C. Here, we summarize the recent findings of viral hepatitis animal models, focusing on the tree shrew animal model and its modeling strategy. |
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| Keywords: | Viral hepatitis Hepatitis B virus Hepatitis C virus Tree shrews Animal model |
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