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Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells |
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| Authors: | Naotoshi Sugimoto Osamu Shido Kentaro Matsuzaki Masanori Katakura Yoshiaki Hitomi Masao Tanaka Toshioki Sawaki Yoshimasa Fujita Takafumi Kawanami Yasufumi Masaki Toshiro Okazaki Hiroyuki Nakamura Shoichi Koizumi Akihiro Yachie Hisanori Umehara |
| Institution: | 1. Department of Physiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan 2. Department of Environmental Physiology, School of Medicine, Shimane University, Izumo, Japan 3. Department of Public Health, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan 4. Department of Hematology and Immunology, Kanazawa Medical University, Uchinada, Japan 5. United Graduate School of Child Development, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan 6. Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan |
| Abstract: | Long-term continuous exposure to high ambient temperatures induces complete heat acclimation in humans and animals. However, to date, the effects of long-term exposure to heat stress on cells have not been fully evaluated. In this study, we investigated an adaptive physiological process induced in culture cells by continuous exposure to mild heat stress for 60 days. The results of this investigation provide evidence that after long-term heat acclimation in cells, (1) heat shock protein levels are increased, (2) hypoxia inducible factor-1α (HIF-1α) expression is upregulated, and (3) heat shock-induced and hypoxia-induced apoptoses are attenuated. These results suggest that the hypoxia response pathway is an intrinsic part of the heat acclimation repertoire and that the HIF-1 pathway following long-term heat acclimation induces cells with cross tolerance against hypoxia. |
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