首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Increased expression of hepatic DNA methyltransferase in smokers
Authors:GJ Hammons  Y Yan  NG Lopatina  B Jin  C Wise  EB Blann  LA Poirier  FF Kadlubar  BD Lyn-Cook
Institution:(1) Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA
Abstract:The DNA methyltransferase enzyme (DNA MTase) catalyzes DNA methylation at cytosines in CpG dinucleotides. 5-Methylcytosine modification of DNA is important in gene regulation, DNA replication, chromatin organization and disease. Increased levels of DNA MTase have been associated with the initiation and promotion of cancer. This study was conducted to assess whether cigarette smoking and other factors, such as age and gender, influence DNA MTase expression in nontumorous tissue. DNA MTase was significantly (p<0.05) higher in samples from cigarette smokers; the mean level of DNA MTase mRNA was almost 2-fold higher in these samples than in those from nonsmokers. Levels of DNA MTase mRNA were higher in samples from females than in those from males, but the difference was not statistically significant. Age was not associated with DNA MTase levels. Increased levels of DNA MTase in individuals who smoke may indicate a greater susceptibility to the risk of cancer since increased levels of this enzyme are found in cancer cell lines and human tumors. The results of this study suggest that further investigations of increased expression of this enzyme as a predisposing factor for cancer susceptibility are needed. This revised version was published online in July 2006 with corrections to the Cover Date.
Keywords:human DNA methyltransferase  smoking
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号