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A cell division-active protein from E. coli |
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| Authors: | A Caprioli G Donelli V Falbo R Possenti L G Roda G Roscetti F M Ruggeri |
| Affiliation: | 1. Laboratorio di Ultrastrutture, Istituto Superiore di Sanita, Rome, Italy;2. Cattedra di Tecnica Fisiologica, “Tor Vergata” University, Rome, Italy;3. Laboratorio di Farmacologia, University of Ancona, Ancona, Italy |
| Abstract: | A purification procedure for a protein obtained from an pathogenic strain of E. coli is described. The protein-called CNF-is active in inhibiting the duplication of cultured mammalian cells. Since nuclei division is apparently normal, treatment of cultured cells with CNF leads to the formation of gigantic, polynucleated cells. The purified protein is chromatographically and electrophoretically homogeneous. A partial characterization of CNF protein is also given. |
| Keywords: | To whom correspondence should be addressed. Mailing address: Cattedra di Tecnica Fisiologica Università “La Sapienza” Piazzale A. Moro 2 00185 Rome Italy. |
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