Susceptibility of neuroactive peptides to aminopeptidase digestion is related to molecular size. |
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Authors: | B M Austen C J Evans D G Smyth |
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Affiliation: | National Institute for Medical Research, Mill Hill, London NW7 1AA UK |
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Abstract: | Peptide fragments derived from the NH2-terminus of corticotropin were found to exhibit widely differing degrees of stability to degradation by aminopeptidase M. Corticotropin itself was 135 times more stable than its NH2-terminal pentapeptide, and similar differences in stability were observed with peptides derived from the B-chain of bovine insulin. Enkephalin linked covalently to the A-chain of bovine insulin was at least 100 times more stable than the pentapeptide. The results demonstrate that the molecular size of a peptide is one factor that determines its NH2-terminal stability. |
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