Association Between Apolipoprotein E Gene Polymorphism and Myocardial Infarction |
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Authors: | Parthasaradhireddy Tanguturi Bhoomireddy Pullareddy P Sampath Kumar Dwarkanath K Murthy |
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Institution: | 1. Department of Genetics, Osmania University, Hyderabad, 500013, Andhra Pradesh, India 2. Department of Cell and Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad, 500013, Andhra Pradesh, India 3. Cardiology Department, Osmania General Hospital, Hyderabad, Andhra Pradesh, India
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Abstract: | We investigated apolipoprotein E (APOE) genotypic influence on myocardial infarction risk in South India, where the disease is emerging as a major threat to the public health care system. The study included 412 subjects: 202 myocardial infarction patients and 210 age- and sex-matched controls. DNA was isolated, the polymorphism of the APOE gene was subjected to PCR, and lipid levels were evaluated. The prevalence of E3/E4 genotypes in patients (18.3%) was 1.5-fold that of controls (11.0%, p < 0.05), and the prevalence of E2/E3 genotypes was higher in controls (6.7%) than in patients (4%). The ε4 allele was significantly associated with myocardial infarction: χ 2 = 12.4; OR 2.2 (CI 95%: 1.4–3.4), p < 0.004, for ε4 versus ε3 and χ 2 = 5.7; OR 2.7 (CI 95%: 1.1–6.5), p > 0.01, for ε4 versus ε2. A significant association of the ε4 allele, especially the E3/E4 genotype, with myocardial infarction was observed. |
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