Microtubules,dendritic spines and spine apparatuses |
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| Authors: | Dr. L. E. Westrum D. Hugh Jones E. G. Gray J. Barron |
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| Affiliation: | (1) Departments of Neurological Surgery and Biological Structure, University of Washington, Seattle, Washington, USA;(2) National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK;(3) Department of Neurological Surgery, University of Washington, RI-20, 98195 Seattle, Washington, USA |
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| Abstract: | Summary Using techniques for enhanced microtubular preservation, including albumin pretreatment (Gray, 1975), occipital cortex of rats was studied electron microscopically at various ages of development. A close structural relationship was seen between microtubules, sacs of SER and the postsynaptic  thickening in primordial spines and with the dense plate material of spine apparatuses. Stereoscopic preparations in addition show a more complicated substructure than previously described for the plate. Microtubules may contribute to the formation of the plate of the spine apparatus which in turn is associated with the postsynaptic thickening of the mature spine. Possible functional correlates are discussed.Dr. L.E. Westrum is an affiliate of the CDMRC at the University of Washington and a recipient of a Burroughs-Wellcome (USA) — Wellcome Trust (U.K.) Research Travel Grant. The research was also supported in part by NIH Grants NS 09678, NS 04053 (NINCDS) and DE 04942 (NIDR), DHHS |
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| Keywords: | Microtubules Dendritic spine apparatus Synapse Development Electron microscopy |
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