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Sterol level in Saccharomyces cerevisiae mutants with altered ergosterol biosynthesis |
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| Authors: | N P Mikha?lova T E Ogorodnikova K A V'iunov |
| Abstract: | The sterol content in Saccharomyces cerevisiae mutants defective in the synthesis of cyclic ergosterol precursors has been studied. It was found that strains with mutational blocks involving the stages of zymosterol side chain methylation at C24 and delta 8----delta 7 isomerization accumulated twice more sterols as compared to parent strains. Regulation of the ergosterol biosynthesis is discussed. |
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