Human glucagon-like peptides 1 and 2 activate rat brain adenylate cyclase |
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Authors: | N M Hoosein R S Gurd |
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Institution: | 1. Laboratoire de Physiologie Cellulaire, Case 901, Faculte des Sciences de Luminy, France;2. Centre D''Immunologie, Case 906, 70 route Leon Lachamp, 13288 Marseille Cedex 9, France |
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Abstract: | Two human glucagon-like peptides, GLP-1 and GLP-2, which are coencoded with pancreatic glucagon in the preproglucagon gene, do not significantly inhibit 125I]monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes. Nevertheless, GLP-1 and GLP-2 were each found to be potent stimulators of both rat hypothalamic and pituitary adenylate cyclase. Only 30-50 pM concentrations of each peptide elicited half-maximal adenylate cyclase stimulation. Our data suggest that GLP-1 and GLP-2 may be neurotransmitters and/or neuroendocrine effectors, which would account for their high degree of sequence conservation through vertebrate evolution. |
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Keywords: | Yeast Plasma membrane protein Antibody SDS-PAGE SDS-polyacrylamide gel electrophoresis |
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