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Highly informative dinucleotide repeat polymorphism at the D11S29 locus on chromosome 11q23 |
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| Authors: | L. Warnich I. Groenewald L. Theart A. E. Retief |
| Affiliation: | (1) MRC Cytogenetics Research Unit, Department of Human Genetics, Tygerberg Hospital, P.O. Box 19063, 7505 Tygerberg, Republic of South Africa;(2) Department of Human Genetics, Faculty of Medicine, University of Stellenbosch, P.O.Box 19063, 7505 Tygerberg, Republic of South Africa |
| Abstract: | Summary The informativeness of locus D11S29 as a genetic marker was improved by the identification of a highly polymorphic (GT)n repeat within the locus. Ten alleles were identified in parents of 40 Centre d'Etude du Polymorphisme Humain families and the polymorphism information content (PIC) was 0.77. The increased PIC value thus enables refinement of the linkage map of 11q23. |
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