| 大鼠突触体钙调神经磷酸酶内源底物的研究 |
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| 引用本文： | 阎力君 魏群. 大鼠突触体钙调神经磷酸酶内源底物的研究[J]. Acta biochimica et biophysica Sinica, 1997, 29(5): 513-516 |
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| 作者姓名： | 阎力君 魏群 |
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| 作者单位： | 北京师范大学分子生物学及生物化学研究室 |
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| 摘 要： | 大鼠突触体钙调神经磷酸酶内源底物的研究阎力君魏群（北京师范大学分子生物学及生物化学研究室，北京１００８７５）关键词钙调神经磷酸酶；内源底物；突触体；电泳图谱的扫描和分析收稿日期：１９９６－１１－１１；接受日期：１９９６－１２－２４。＊国家自然科学基金...
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| 关 键 词： | 钙调神经 磷酸酶 内源底物 底物 突触体 |
Study on Endogenous Substrates for Calcineurin in Rat Synaptosome |
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| YAN Li Jun and WEI Qun. Study on Endogenous Substrates for Calcineurin in Rat Synaptosome[J]. Acta biochimica et biophysica Sinica, 1997, 29(5): 513-516 |
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| Authors: | YAN Li Jun and WEI Qun |
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| Abstract: | The inhibition of endogenous calcineurin activity with polyclonal antibody revealed the presence of 11 phosphoprotein substrates for this enzyme in adult rat cerebral cortex synaptosome as studied by high resolution two dimensional PAGE and autoradiography. The changes of these endogenous substrates for calcineurin from newborn rat and adult rat cerebral cortex synaptosome were analyzed quantitatively by using digital image scanning system based on the 2 D software and simultaneous, comparison with those of whole rat brain was made. Some of them were shown to be expressed at higher levels on postnatal day 3 and believed to be the neuromodulin/GAP 43 as reported in its literature. The important role of calcineurin in nerve growth and development was discussed. |
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| Keywords: | Calcineurin Endogenous substrate Synaptosome Electro phoretic pattern scanning and analysis |
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