Comparative In Vitro Study of Six Carbamazepine Products |
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Authors: | Pavan Kumar Mittapalli Bandari Suresh S S Q Hussaini Yamasani Madhusudan Rao Shashank Apte |
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Institution: | (1) University College of Pharmaceutical Sciences, Kakatiya University, Warangal, 506 009, Andhra Pradesh, India |
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Abstract: | The purpose of present study was to evaluate commercial preparations of carbamazepine tablets with respect to drug release
through a defined sequence of experiments using Minitab software. The compliance of products with respect to United States
Pharmacopeia (USP) dissolution test and comparison of the products with respect to drug release in different dissolution conditions
is reported in the present paper. The different dissolution conditions studied include dissolution medium (1% SLS in purified
water, 0.1 N HCl), volume (900 and 1,000 ml), rpm (50 rpm, 75 rpm). Studies indicated that all six products complied with
USP dissolution criteria. However, the extent of influence of dissolution conditions on drug release was varied among the
products. Distinct dissolution profiles were observed and there was no correlation with disintegration time in certain products.
The in vitro dissolution experimentation helped in identifying the discriminatory dissolution conditions and also the formulations that
were unaffected with change of dissolution variables. In summary, commercial preparations of carbamazepine vary widely in
their dissolution behavior in multi dissolution run experimentation. Identifying this behavior of the products was essential
as an in vitro tool for screening a good and a bad formulation. |
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Keywords: | carbamazepine dissolution drug release sodium lauryl sulfate |
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