Streptozotocin-induced diabetes produces alterations in adenylate cyclase in rat cerebrum, cerebral microvessels and retina |
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Authors: | G C Palmer G L Wilson R B Chronister |
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Institution: | 1. Departments of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA;2. Departments of Pharmacology and Anatomy, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA;3. Frist-Massey Neurological Institute, 356 24th Ave. N., Nashville, Tennessee 37203, USA |
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Abstract: | Eight weeks following streptozotocin-induced diabetes mellitus in rats, the sensitivity of adenylate cyclase to dopamine (DA) and norepinephrine (NE) was reduced in homogenates of retina. Furthermore, the activation of adenylate cyclase in cerebral microvessels (capillaries) by NE, 5'-guanylyl imidodiphosphate (alone or with NE) and forskolin was reduced in diabetic rats versus appropriate controls. In diabetic rats enzyme sensitivity to only NE was attenuated in homogenates of cerebral cortex and cortical piaarachnoid. No differences between controls and diabetics were noted with respect to guanylate cyclase or cyclic AMP phosphodiesterases. The damage observed in retina and microvessels may play an important pathogenic role in diabetes-induced blindness and stroke. |
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