Charybdotoxin blocks cation-channels in the vacuolar membrane of suspension cells of Chenopodium rubrum L. |
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Authors: | T Weiser F W Bentrup |
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Affiliation: | Botanisches Institut der Justus-Liebig-Universit?t, Giessen, F.R.G. |
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Abstract: | Using the patch-clamp technique, we studied the action of charybdotoxin which blocks Ca(2+)-activated large-conductance K+ channels in animal tissue on the slow-activating (SV), Ca(2+)-activated cation channel in the vacuolar membrane of suspension-cells of Chenopodium rubrum L. The toxin reversibly reduced the vacuolar current with EC50 approximately 20 nM suggesting structural similarities between ion channels in animal and plant membranes. |
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