Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors |
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| Authors: | Friedman Scott L Nieto Natalia |
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| Institution: | Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA. scott.friedman@mssm.edu |
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| Abstract: | Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycerol (2-AG) after ethanol feeding, leading to paracrine stimulation of hepatocyte CB1 receptors. |
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