The dopamine receptor adenylate cyclase complex: Evidence for post recognition site involvement for the development of supersensitivity |
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Authors: | M. Parenti S. Gentleman M. C. Olianas N. H. Neff |
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Affiliation: | (1) Laboratory of Preclinical Pharmacology National Institute of Mental Health, Saint Elizabeths Hospital, 20032 Washington, D.C. |
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Abstract: | The dopamine receptor adenylate cyclase complex of a rat striatal membrane preparation became more responsive to dopamine following the injection of 6-hydroxydopamine (6-OHDA) into the median forebrain bundle or following the subcutaneous implantation of morphine pellets. Moreover, the membrane cyclase system was more responsive to activation by GTP, guanyl-5-yl-imidodiphosphate and Mn-ATP. These observations suggest that both 6-OHDA and morphine induce similar biochemical changes in striatum and that the increased responsiveness arises, in part, from modification of the nucleotide regulatory and/or catalytic components of adenylate cyclase. |
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