Indentification of two somatomedin A active polypeptides and in vivo effects of a somatomedin A concentrate |
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Authors: | L Fryklund K Uthne H Sievertsson |
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Affiliation: | AB Kabi, The Recip Polypeptide Laboratory, S-104 25 Stockholm, Sweden |
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Abstract: | The first chemical characterization of two polypeptides from human serum which stimulate the incorporation of 35S sulfate into chick cartilage is described. These two polypeptides, designated Somatomedin A1 and A2 have a molecular weight of approximately 7000. Although each peptide contains 1 cysteine residue and has asparagine as amino terminal residue, there are apparent differences in the amino acid composition. Administration of a Somatomedin A concentrate to hypophysectomized rats gave an increase in tibial width similar to that obtained with 20 μg human growth hormone. |
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