Cellular stress response cross talk maintains protein and energy homeostasis |
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| Authors: | Cynthia L Swan Lea Sistonen |
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| Institution: | 1Department of Biosciences, Åbo Akademi University, Turku, Finland;2Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland |
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| Abstract: | Maintenance of cellular homeostasis depends upon several pathways that allow a cell to respond and adapt to both environmental stress and changes in metabolic status. New work in this issue of The EMBO Journal reveals a mechanism of cross talk between heat shock factor 1 (HSF1), the primary regulator of the proteotoxic stress response, and AMP‐activated protein kinase (AMPK), the primary sensor in the metabolic stress response. |
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