Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae. |
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| Authors: | J M Song S Picologlou C M Grant M Firoozan M F Tuite S Liebman |
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| Affiliation: | Department of Biological Sciences, University of Illinois, Chicago 60680. |
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| Abstract: | Changes in the dosage of genes encoding elongation factor EF-1 alpha were shown to cause parallel changes in the misreading of nonsense codons. Higher amounts of EF-1 alpha were correlated with increased nonsense suppression, suggesting that the level of EF-1 alpha is critically involved in translational fidelity. |
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