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Regional mapping of clotting factors VII and X to 13q34. Expression of factor VII through chromosome 8 |
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| Authors: | J de Grouchy Marie-Dominique Dautzenberg Catherine Turleau Suzette Beguin Françoise Chavin-Colin |
| Institution: | (1) U.173 INSERM, Laboratoire de Cytogénétique Humaine et Comparée, Hôpital Necker-Enfants-Malades, 149 rue de Sèvres, F-75743 Paris Cedex 15, France;(2) ER.149 CNRS, Laboratoire de Cytogénétique Humaine et Comparée, Hôpital Necker-Enfants-Malades, 149 rue de Sèvres, F-75743 Paris Cedex 15, France;(3) Laboratoire Central d'Hématologie et Immunologie (Prof. P. Cornu), Hôpital Necker-Enfants-Malades, 149 rue de Sèvres, F-75743 Paris Cedex 15, France |
| Abstract: | Summary Blood clotting factors were investigated in a patient with trisomy 8 mosaicism, a patient with an r(13), and a patient with distal trisomy 13q. Results are compatible with the assignment of the structural genes of factors VII and X to 13q34 and the existence of a regulatory mechanism associated with chromosome 8 controlling the expression of factor VII alone. |
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