|
|||||
|
|
| Non-Viral Deoxyribonucleoside Kinases——Diversity and Practical Use | |
| 摘 要： | |
Non-Viral Deoxyribonucleoside Kinases-Diversity and Practical Use |
|
| Authors: | Louise Slot Christiansen Birgitte Munch-Petersen Wolfgang Knecht |
| Institution: | 1. Department of Biology, Lund University, Lund 22362, Sweden 2. Department of Biology, Lund University, Lund 22362, Sweden;Department of Science, Systems and Models, Roskilde University, Roskilde 4000, Denmark 3. Department of Biology, Lund University, Lund 22362, Sweden;Lund Protein Production Platform Lund University, Lund 22362, Sweden |
| Abstract: | Deoxyribonucleoside kinases(d NKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. d Nks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian d NKs has therefore always been of great medical interest. However, during the last 20 years, research on d NKs has gone into nonmammalian organisms. In this review, we focus on non-viral d NKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation. |
| Keywords: | Nucleosides Nucleotides Nucleoside salvage pathway Evolution Suicide gene therapy Deoxynucleosides Deoxynucleotides Deoxynucleoside kinases |
| 本文献已被 CNKI 等数据库收录！ | |