Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam |
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| Authors: | Li Pan Young-Won Chin Hee-Byung Chai Tran Ngoc Ninh Djaja Djendoel Soejarto A. Douglas Kinghorn |
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| Affiliation: | 1. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA;2. Institute of Ecology and Biological Resources, Vietnamese Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam;3. Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, IL 60612, USA |
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| Abstract: | Five new triterpenoids (1–5), together with two known quassinoids, bruceantin (6) and bruceine A (7), and a known flavonolignan, (?)-hydnocarpin (8), were isolated from the chloroform-soluble subfraction of a methanol extract of the combined twigs, leaves, and inflorescence of Brucea javanica collected in Vietnam. The structures of the new compounds 1–5 were established on the basis of spectroscopic methods. All isolates were evaluated for cytotoxicity against a small panel of human cancer cell lines. Quassinoids 6 and 7 were found to be highly active against these cell lines. (?)-Hydnocarpin (8) showed a potentiating effect when combined with both 6 and 7, during cytotoxicity testing using the MCF-7 human breast cancer cell line. |
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