Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one,HB2 |
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| Authors: | Niraldo Paulino Naiara Carvalho Rodrigues Paulo Celso Pardi José Agustín Pablo Quincoces Suárez Reginaldo Pereira dos Santos Amarilis Scremin Christian Vogel Holger Feist Dirk Michalik |
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| Affiliation: | 1. Grupo de Pesquisa e Desenvolvimento de Biomedicamentos (BIOMED), Universidade Bandeirante de São Paulo, Rua Maria Cândida 1813, Vila Guilherme, São Paulo, SP, Brazil;2. Laboratório de Síntese Orgânica, Universidade Bandeirante de São Paulo, Rua Maria Cândida 1813, Vila Guilherme, São Paulo, SP, Brazil;3. Laboratório de Controle de Qualidade, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil;4. Institut für Chemie, Universität Rostock, Germany;5. Leibniz—Institut für Katalyse, Rostock, Germany |
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| Abstract: | This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E2 production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice. |
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