A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa |
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| Authors: | Takahiro Yamashita Yoichi Nakao Shigeki Matsunaga Tsutomu Oikawa Yukimitsu Imahara Nobuhiro Fusetani |
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| Institution: | 1. Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan;2. School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;3. Kanagawa University of Human Services, 1-10-1 Heisei-cho, Yokosuka, Kanagawa 238-8522, Japan;4. Wakayama Prefectural Museum of Natural History, 370-1, Funao, Kainan, Wakayama 642-0001, Japan;5. Faculty of Fisheries Sciences, Hokkaido University, 3-1-1 Minato-cho, Hakodate 041-8611, Japan |
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| Abstract: | A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20–40 μM. |
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