Enaminones 10. Molecular modeling aspects of the 5-methylcyclohexenone derivatives |
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| Authors: | Ainsley Gibson John Harkless Mariano Alexander KR Scott |
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| Institution: | 1. Department of University Informational Services, Georgetown University, Washington, DC 20057, United States;2. Department of Chemistry, Howard University, Washington, DC 20059, United States;3. Department of Pharmaceutical Sciences, School of Pharmacy, Howard University, Washington, DC 20059, United States |
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| Abstract: | This article expands upon our original submission to the Eddington, N. D.; Cox, D. S.; Khurana, M.; Salama, N. N.; Stables, J. P.; Harrison, S. J.; Negussie, A.; Taylor, R. S.; Tran, U. Q.; Moore, J. A.; Barrow, J. C.; Scott, K. R. Eur. J. Med. Chem. 2003, 38, 49 on a series of twenty (20) compounds, all 5-methyl-3-(substituted)-phenylamino]-cyclohex-2-enone derivatives. This article provides the reasons why the compounds are active/inactive. By use of computational methods, the reasons for activity/inactivity are explained. |
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