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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
Authors:John D. Hayes  Michael McMahon
Affiliation:1. A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio FIN-70211, Finland;2. Institute of Biomedicine, University of Eastern Finland, Kuopio FIN-70211, Finland;1. Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, PR China;2. Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, PR China;1. MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK;2. School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong, People?s Republic of China;3. Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK;4. Unit for Transplantation Surgery, Department of Clinical Science, Intervention, and Technology, Karolinska University Hospital Huddinge, Stockholm, Sweden;5. Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden;6. Department of Hepatobiliary Surgery, Aintree University Hospital NHS Foundation Trust, Liverpool, UK
Abstract:
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