Synthesis and antimicrobial evaluation of some new substituted purine derivatives |
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Authors: | Meral Tunçbilek Zeynep Ateş-Alagöz Nurten Altanlar Arzu Karayel Süheyla Özbey |
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Affiliation: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tando?an, Ankara, Turkey;2. Department of Microbiology, Faculty of Pharmacy, Ankara University, 06100 Tando?an, Ankara, Turkey;3. Department of Physics Engineering, Hacettepe University, 06800 Beytepe, Ankara, Turkey |
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Abstract: | A series of 8,9-disubstituted adenines (4, 5, 8), 6-substituted aminopurines (10–13) and 9-(p-fluorobenzyl/cyclopentyl)-6-substituted aminopurines (16, 17, 19–30) have been prepared and the antimicrobial activities of these compounds against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA, standard and clinical isolate), Bacillus subtilis, Escherichia coli and Candida albicans were evaluated. 6-[(N-phenylaminoethyl)amino]-9H-purine (12) which has no substitution at N-9 position and 9-cyclopentyl-6-[(4-fluorobenzyl)amino]-9H-purine (24) exhibited excellent activity against C. albicans with MIC 3.12 μg/mL. These compounds displayed better antifungal activity than that of standard oxiconazole. Furthermore, compound 22 carrying 4-chlorobenzylamino group at the 6-position of the purine moiety exhibited comparable antibacterial activity with that of the standard ciprofloxacin against both of the drug-resistant bacteria (MRSA, standard and clinical isolate). |
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