Synthesis,antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides |
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| Authors: | Alessandro K Jordão Vitor F Ferreira Emerson S Lima Maria CBV de Souza Eduardo CL Carlos Helena C Castro Reinaldo B Geraldo Carlos R Rodrigues Maria CB Almeida Anna C Cunha |
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| Institution: | 1. Universidade Federal Fluminense, Departamento de Química Orgânica, Outeiro de São João Batista, s/n°, Niterói, 24020-141 Rio de Janeiro, Brazil;2. Universidade Federal do Amazonas, Faculdade de Ciências Farmacêuticas, Rua Alexandre Amorin, 330, Manaus, 69010-300 Amazonas, Brazil;3. Universidade Federal Fluminense, Departamento de Biologia Celular e Molecular, LABioMol, Niterói, 24020-141 Rio de Janeiro, Brazil |
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| Abstract: | This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (2a–j). These compounds were synthesized, characterized and screened for their in vitro antiplatelet profile against human platelet aggregation using arachidonic acid, adrenaline and ADP as agonists. Among NAH derivatives 2a–j, the compounds 2a, 2c, 2e, 2g and 2h were the most promising molecules with significant antiplatelet activity. |
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