2-Benzoylpyridine-N(4)-tolyl thiosemicarbazones and their palladium(II) complexes: Cytotoxicity against leukemia cells |
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| Authors: | Karina SO Ferraz Lucas Ferandes Diego Carrilho Mauro CX Pinto Maria de Fátima Leite Elaine M Souza–Fagundes Nivaldo L Speziali Isolda C Mendes Heloisa Beraldo |
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| Institution: | 1. Departamento de Química, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil;2. Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil;3. Departamento de Física, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil |
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| Abstract: | The palladium(II) complexes Pd(2Bz4oT)Cl], Pd(2Bz4mT)Cl], and Pd(2Bz4pT)Cl] were prepared with N(4)-ortho- (H2Bz4oT) N(4)-meta- (H2Bz4mT) and N(4)-para- (H2Bz4pT) tolyl-thiosemicarbazones derived from 2-benzoylpyridine. The free thiosemicarbazones proved to be highly cytotoxic against Jurkat, HL60 and the resistant HL60.Bcl-XL leukemia cell lines at nanomolar concentrations, but were much less cytotoxic to HepG2 human hepatoma cells. Upon coordination to palladium(II) the cytotoxic activity against all studied cell lines decreases. However, the high cytotoxicity of the free thiosemicarbazones against leukemia, together with their hepatotoxic profile similar to that of cisplatin suggest that N(4)-tolyl thiosemicarbazones have potential as chemotherapeutic drug candidates. |
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